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KMID : 0606920060140040216
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Biomolecules & Therapeutics
2006 Volume.14 No. 4 p.216 ~ p.219
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Effects of the Constituents of Paeonia lactiflora Root on Arachidonate and NO Metabolism
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Choi Young-Hwan
Gu Lian-yu
Kim Yeong-Shik
Kang Sam-Sik
Kim Ju-Sun
Yean Min-Hye
Kim Hyun-Pyo
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Abstract
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In order to establish the anti-inflammatory cellular mechanism of the paeony root (Paeonia lactiflora, Pall, Paeoniaceac), the constituents including paeoniflorin, albiflorin, (+)-catechin, paeonol, benzoic acid and methyl gallate were evaluated for their effects on arachidonate and NO metabolism. Among the compounds tested. only paeonol weakly inhibited cyclooxygenase-2-mediated PGE2 production from LPS-treated RAW 264.7 cells. (+)-Catechin and methyl gallate weakly inhibited inducible nitric oxide synthase-mediated NO pro- duction from the same cell line. In particular, methyl gallate significantly inhibited 5-lipoxygenase from RBL-1 cells with an IC50 of 8.4 μM. These results suggest that the inhibition of these components on arachidonate and NO metabolism may contribute at leat in part to anti-inflammatory mechanism of the paeony root.
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KEYWORD
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Paeonia lactiflora, cyclooxygenase, nintc oxide synthase, lipoxygenase, methyl gallate
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